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The representative images and histogram of the % cell lysis of anti-FRα-CAR-T cells (produced from pooled results from HD01 to HD 05) <t>and</t> <t>anti-FAP@OMF-NPs</t> in 3D M10A/HDFa HSs, M10A/004CAFs HSs, M10A/130CAFs HSs, and M10A/132CAFs HSs. (A) Fluorescence images (green color = cancer and red = CAFs) of 3D M10A/HDFa HSs, M10A/004CAFs HSs, M10A/130CAFs HSs, and M10A/132CAFs HSs after being treated with various treatment conditions for 48 h. (B) Percentage of cell lysis (green = cancer) of different spheroids at 48 h post-treatment (# indicates p < 0.05 compared to M10A/HDFa HSs). (C) Percentage of cell lysis (red = CAFs) of different spheroids at 48 h post-treatment (# indicates p < 0.05 compared to M10A/HDFa HSs and $ indicates p < 0.05 compared to M10A/004CAFs HSs). The results are summarized from five independent experiments (one experiment for one HD, in a total of 5 donors).
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The representative images and histogram of the % cell lysis of anti-FRα-CAR-T cells (produced from pooled results from HD01 to HD 05) <t>and</t> <t>anti-FAP@OMF-NPs</t> in 3D M10A/HDFa HSs, M10A/004CAFs HSs, M10A/130CAFs HSs, and M10A/132CAFs HSs. (A) Fluorescence images (green color = cancer and red = CAFs) of 3D M10A/HDFa HSs, M10A/004CAFs HSs, M10A/130CAFs HSs, and M10A/132CAFs HSs after being treated with various treatment conditions for 48 h. (B) Percentage of cell lysis (green = cancer) of different spheroids at 48 h post-treatment (# indicates p < 0.05 compared to M10A/HDFa HSs). (C) Percentage of cell lysis (red = CAFs) of different spheroids at 48 h post-treatment (# indicates p < 0.05 compared to M10A/HDFa HSs and $ indicates p < 0.05 compared to M10A/004CAFs HSs). The results are summarized from five independent experiments (one experiment for one HD, in a total of 5 donors).
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Image Search Results


The representative images and histogram of the % cell lysis of anti-FRα-CAR-T cells (produced from pooled results from HD01 to HD 05) and anti-FAP@OMF-NPs in 3D M10A/HDFa HSs, M10A/004CAFs HSs, M10A/130CAFs HSs, and M10A/132CAFs HSs. (A) Fluorescence images (green color = cancer and red = CAFs) of 3D M10A/HDFa HSs, M10A/004CAFs HSs, M10A/130CAFs HSs, and M10A/132CAFs HSs after being treated with various treatment conditions for 48 h. (B) Percentage of cell lysis (green = cancer) of different spheroids at 48 h post-treatment (# indicates p < 0.05 compared to M10A/HDFa HSs). (C) Percentage of cell lysis (red = CAFs) of different spheroids at 48 h post-treatment (# indicates p < 0.05 compared to M10A/HDFa HSs and $ indicates p < 0.05 compared to M10A/004CAFs HSs). The results are summarized from five independent experiments (one experiment for one HD, in a total of 5 donors).

Journal: International Journal of Biological Sciences

Article Title: Dual Targeting of FAP-Directed Nanoparticles and FRα-Specific CAR-T Cells Induces Additive Anti-Tumor Effects in Triple-Negative Breast Cancer

doi: 10.7150/ijbs.122417

Figure Lengend Snippet: The representative images and histogram of the % cell lysis of anti-FRα-CAR-T cells (produced from pooled results from HD01 to HD 05) and anti-FAP@OMF-NPs in 3D M10A/HDFa HSs, M10A/004CAFs HSs, M10A/130CAFs HSs, and M10A/132CAFs HSs. (A) Fluorescence images (green color = cancer and red = CAFs) of 3D M10A/HDFa HSs, M10A/004CAFs HSs, M10A/130CAFs HSs, and M10A/132CAFs HSs after being treated with various treatment conditions for 48 h. (B) Percentage of cell lysis (green = cancer) of different spheroids at 48 h post-treatment (# indicates p < 0.05 compared to M10A/HDFa HSs). (C) Percentage of cell lysis (red = CAFs) of different spheroids at 48 h post-treatment (# indicates p < 0.05 compared to M10A/HDFa HSs and $ indicates p < 0.05 compared to M10A/004CAFs HSs). The results are summarized from five independent experiments (one experiment for one HD, in a total of 5 donors).

Article Snippet: To conjugate human anti-FAP antibody (MAB3715, R&D System) to lyophilised NPs, the synthesised NPs were activated.

Techniques: Lysis, Produced, Fluorescence

The representative images and histogram of the % cell lysis of anti-FRα-CAR-T cells (produced from pooled results from HD01 to HD 05) and anti-FAP@OMF-NPs. (A) Fluorescence images (green color = cancer and red = CAFs) of 3D M231/HDFa HSs, M231/004CAFs HSs, M231/130CAFs HSs, and M231/132CAFs HSs after being treated with various treatment conditions for 48 h. (B) Percentage of cell lysis (green = cancer) of different spheroids at 48 h post-treatment (# indicates p < 0.05 compared to M231A/HDFa HSs and $ indicates p < 0.05 compared to M231/004CAFs HSs). (C) Percentage of cell lysis (red = CAFs) of different spheroids at 48 h post-treatment. (D) Percentage of cell lysis (green + red signal) of 3D M231/HDFa HSs, M231/004CAFs HSs, M231/130CAFs HSs, and M231/132CAFs HSs. The results are summarized from five independent experiments (one experiment for one HD, in a total of 5 donors). NS = not significance. *p < 0.05, ***p < 0.01, ***p < 0.001, and ****p < 0.0001. The scale bar is 100 μm.

Journal: International Journal of Biological Sciences

Article Title: Dual Targeting of FAP-Directed Nanoparticles and FRα-Specific CAR-T Cells Induces Additive Anti-Tumor Effects in Triple-Negative Breast Cancer

doi: 10.7150/ijbs.122417

Figure Lengend Snippet: The representative images and histogram of the % cell lysis of anti-FRα-CAR-T cells (produced from pooled results from HD01 to HD 05) and anti-FAP@OMF-NPs. (A) Fluorescence images (green color = cancer and red = CAFs) of 3D M231/HDFa HSs, M231/004CAFs HSs, M231/130CAFs HSs, and M231/132CAFs HSs after being treated with various treatment conditions for 48 h. (B) Percentage of cell lysis (green = cancer) of different spheroids at 48 h post-treatment (# indicates p < 0.05 compared to M231A/HDFa HSs and $ indicates p < 0.05 compared to M231/004CAFs HSs). (C) Percentage of cell lysis (red = CAFs) of different spheroids at 48 h post-treatment. (D) Percentage of cell lysis (green + red signal) of 3D M231/HDFa HSs, M231/004CAFs HSs, M231/130CAFs HSs, and M231/132CAFs HSs. The results are summarized from five independent experiments (one experiment for one HD, in a total of 5 donors). NS = not significance. *p < 0.05, ***p < 0.01, ***p < 0.001, and ****p < 0.0001. The scale bar is 100 μm.

Article Snippet: To conjugate human anti-FAP antibody (MAB3715, R&D System) to lyophilised NPs, the synthesised NPs were activated.

Techniques: Lysis, Produced, Fluorescence

Measurements of secreted cytokines in (A) HD01, (B) HD02, and (C) HD05 including (D) IL-2, (E) IL-4, (F) IL-10, (G) IL-6, (H) IL-17A, (I) TNF-⍺, (J) sFas, (K) sFasL, (L) IFN-γ, (M) granzyme A, (N) granzyme B, (O) perforin, and (P) granulysin from different treatment conditions of heterospheroids (HSs as target cells), mock T cell, FR⍺-CAR-T cell, anti-FAP@OMF-NPs, and FR⍺-CAR-T cell + anti-FAP@OMF-NPs) after exposure to M231/HDFa and M231/130CAFs HSs. The result represents one independent experiment for each donor. (Q) Proposed mechanism of the study. Created with BioRender.com. # p < 0.05 compared to HSs, * p < 0.05, and *** p < 0.01.

Journal: International Journal of Biological Sciences

Article Title: Dual Targeting of FAP-Directed Nanoparticles and FRα-Specific CAR-T Cells Induces Additive Anti-Tumor Effects in Triple-Negative Breast Cancer

doi: 10.7150/ijbs.122417

Figure Lengend Snippet: Measurements of secreted cytokines in (A) HD01, (B) HD02, and (C) HD05 including (D) IL-2, (E) IL-4, (F) IL-10, (G) IL-6, (H) IL-17A, (I) TNF-⍺, (J) sFas, (K) sFasL, (L) IFN-γ, (M) granzyme A, (N) granzyme B, (O) perforin, and (P) granulysin from different treatment conditions of heterospheroids (HSs as target cells), mock T cell, FR⍺-CAR-T cell, anti-FAP@OMF-NPs, and FR⍺-CAR-T cell + anti-FAP@OMF-NPs) after exposure to M231/HDFa and M231/130CAFs HSs. The result represents one independent experiment for each donor. (Q) Proposed mechanism of the study. Created with BioRender.com. # p < 0.05 compared to HSs, * p < 0.05, and *** p < 0.01.

Article Snippet: To conjugate human anti-FAP antibody (MAB3715, R&D System) to lyophilised NPs, the synthesised NPs were activated.

Techniques: